General Cell Based Assays
Cayman Chemical 2-bromo 17β-Estradiol, Purity: ≥98%, CAS: 15833-07-5, 5 mg
A synthetic steroid and inhibitor of estrogen 2-hydroxylase; inhibits estrogen 2-hydroxylase in rat liver microsomes at 50 and 100 µM; prevents estrogen-induced inhibition of apomorphine-induced climbing behavior in mice at 5 mg/kg
Eurofins Discoverx PathHunter Human PROKR2 β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Human PROKR2 β-Arrestin Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure PROKR2 (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter eXpress AGTRL1 CHO-K1 β-Arrestin GPCR Assay, 10-Plate Kit. (93-0250E2CP0L)
The PathHunter AGTRL1 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. apelin-13) based activation of AGTRL1 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged AGTRL1 and EA-tagged β-Arrestin-2. Activation of AGTRL1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
10X Genomics Inc GEM-X Flex Gene Expression Mouse n-plex, 64 samples
GEM-X Flex Gene Expression Mouse n-plex, 64 samples
Eurofins Discoverx PathHunter eXpress CHRM3 Total Internalization Assay, 10pl Kit. (93-0775E3CP5L)
The PathHunter CHRM3 Total Internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit uses EFC technology to measure ligand-induced internalization of CHRM3 via detection of localization to the early endosome. The included cell line overexpresses ProLink-tagged CHRM3 and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the CHRM3 receptor to the early endosome leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter Mouse EDNRA β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Mouse EDNRA β-Arrestin Stable Cell Line Assay (CHO-K1) contains a stable clonal cell line used to measure mouse EDNRA (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Eurofins Discoverx PathHunter Mouse ADRA1B β-Arrestin Cell-Based Assay Kit (CHO-K1)
The PathHunter Mouse ADRA1B β-Arrestin Stable Cell Pool Assay (CHO-K1) contains a stable engineered cell pool used to measure mADRA1B (GPCR) activity via recruitment of β-Arrestin2. This is a complete kit that includes the cell pool vials, all required culture reagents for maintaining the cells in continuous culture, and detection reagents for running the assay.
Eurofins Discoverx cAMP Hunter eXpress CXCR1 (IL8RA) CHO-K1 GPCR Assay, 2-Plate Kit. (95-0073E2CP2M)
The cAMP Hunter CXCR1 (IL8RA) eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. CXCL8/IL8) based activation of CXCR1 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type CXCR1, a naturally Gi/Go coupled GPCR. Upon activation of CXCR1, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter Human LAIR1 Signaling Cell-Based Assay Kit (Jurkat)
The PathHunter Human LAIR1 (SHP1) Signaling Stable Cell Line Assay (Jurkat) measures LAIR1 signal by recruitment of SH2 domain protein to the activated receptor. This is a complete kit that includes the cell vials and all required reagents needed for cell culture and running the assay.
Cayman Chemical 8-pCPT NAD sodIum salt 800ug
A derivative of NAD+; has been used in the screening of analog-sensitive PARP1 gatekeeper mutations
Eurofins Discoverx PathHunter eXpress CCR6 CHO-K1 β-Arrestin GPCR Assay, 10-Plate Kit. (93-0194E2CP0L)
The PathHunter CCR6 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. CCL20/MIP-3α) based activation of CCR6 GPCR activity via detection of β-arrestin recruitment. The included cell line overexpresses ProLink-tagged CCR6 and EA-tagged β-Arrestin-2. Activation of CCR6 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx PathHunter eXpress CHRM5 Activated GPCR Internalization Assay, 10pl Kit. (93-0657E3CP5L)
The PathHunter CHRM5 Activated GPCR internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit uses EFC technology to measure ligand-induced internalization of CHRM5 via detection of localization to the early endosome. The included cell line overexpresses EA-tagged β-Arrestin-2 as well as a ProLink-tagged early endosome protein and untagged CHRM5. Upon ligand-induced receptor activation, β-Arrestin-2 is recruited to the activated GPCR and the resulting CHRM5-arrestin complex is internalized to the early endosome, leading to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Miltenyi Biotec, Inc. MACSfectin 1mL
Reagent for transfection of adherent and suspension cells maintaining high cell viability
Lonza Walkersville PowerFeed A Bas Powder Kit 10L
PowerFeedA Chemically Defined and Protein-free Powder Kit is a non-animal origin powder feed kit containing all compontent to produce 10L of liquid feed The PowerFeed A Chemically Defined and Protein-free Powder Feed is formulated to maximize cell growth using Lonza CHO cell culture media ProCHO 4 -5 and PowerCHO 2 This BioWhittaker Cell Culture Media is produced according to cGMP and labelled For Further Manufacturing (FFM) GMP Products are intended for research or further manufacturing use only THIS PRODUCT IS NOT INTENDED FOR DIRECT THERAPEUTIC USE IN HUMANS
Abcam MK886, Lipo x ygenase inhibitor, 10MG
MW 494.1 Da, Purity >98%. Potent 5-lipoxygenase activating protein inhibitor (FLAP) (IC₅₀ = 44 nM). Inhibits leukotriene biosynthesis (IC₅₀ = 2.5 nM) in vitro and tumor activity in vivo. Displays PPARα antagonist activity. Orally active in vivo.
The product is subject to the following: Abcam Restricted Use Statement